Current research projects and publications

The WRGL has a strong research ethos, which synergises with the diagnostic service and enables us to keep up with new developments in a rapidly changing and expanding discipline. Our work, much of which is conducted under the auspices of the University of Southampton, is directed at understanding how abnormalities of genes or chromosomes can lead to malignancy, neonatal diabetes, behavioural or developmental abnormalities and other conditions. Over the past four years we have established a strong focus on haematological malignancies and are using conventional chromosome analysis plus new molecular methods to investigate the pathogenesis of myeloproliferative diseases and multiple myeloma.
Our work is resulting in the development of better diagnostic tests, better understanding of fundamental disease processes and also better treatment through the identification of new drug targets and improved risk stratification. We are funded through a range of sources, including the Leukaemia Research Fund, Diabetes UK, the Wellcome Trust, the Department of Health, the Wessex Cancer Trust and HOPE.

We are currently recruiting patients with possible or definite imprinting disorders for a pilot research project to determine the impact of widespread imprinting aberrations in human disorders. Click here to find out more.

Recent publications from the WRGL and Human Genetics Division

2005

2006